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Evaluation of olfactory functions in essential tremor
1Bakirkoy Prof. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Department of Neurology, Istanbul, Turkiye
2Istanbul Training and Research Hospital, Department of Neurology, Istanbul, Turkiye
3Bahcesehir University Faculty of Medicine, Department of Neurology, Istanbul, Turkiye
Dusunen Adam Journal of Psychiatry and Neurological Sciences 2023; 36(4): 216-221 DOI: 10.14744/DAJPNS.2023.00227
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Objective: Recently, non-motor symptoms are increasingly recognized in patients with essential tremors. This study evaluates essential tremor (ET) patients’ olfactory dysfunction, a notable non-motor symptom.
Method: This study included 34 patients with ET and 25 healthy controls. Participants underwent nasal examinations and the Connecticut Chemosensory Clinical Research Center (CCCRC) odor test.
Results: The ET patients had significantly lower CCCRC odor total scores (p=0.044) and odor threshold scores than the control group (p=0.007). However, both groups had similar CCCRC odor discrimination scores (p>0.05). While not statistically significant, a positive correlation was observed between the tremor duration and odor scores (p>0.05).
Conclusion: Our study demonstrates the impairment of olfactory functions in ET patients, reinforcing the notion of a neurodegenerative process. Further large-scale studies examining additional non-motor symptoms could provide deeper insights into the disease’s pathogenesis.